Circulating Soluble Intercellular Adhesion Molecule 1 (sICAM-1) and Subclinical Atherosclerosis: the Coronary Artery Risk Development in Young Adults (CARDIA) Study
نویسندگان
چکیده
RESULTS: Median sICAM-1 was 145.9 g/L. Among a subgroup with advanced atherosclerotic plaque (either CAC or stenosis), IMT was 0.010 (95% CI 0.003– 0.017 mm) higher per SD of sICAM-1 (44 g/L) in a model adjusted for age, race, sex, clinic, smoking, exercise, body size, education, blood pressure, antihypertensive medication, plasma lipids, and cholesterol-lowering medication. With the same adjustment, the odds ratio (OR) for the presence of year-20 carotid artery stenosis per SD of sICAM-1 was 1.12 (95% CI 1.01–1.25, P 0.04), whereas for occurrence of CAC progression the OR was 1.16 (1.04 –1.31, P 0.01). The associations with CAC and carotid stenosis were strongest in the top 20th of the sICAM-1 distribution.
منابع مشابه
Circulating soluble intercellular adhesion molecule 1 and subclinical atherosclerosis: the Coronary Artery Risk Development in Young Adults Study.
BACKGROUND Soluble intercellular adhesion molecule 1 (sICAM-1) is associated with endothelial dysfunction and clinical cardiovascular disease. We investigated the relationship of subclinical atherosclerosis with sICAM-1 concentration. METHODS sICAM-1 concentration was assayed at year 15 of the Coronary Artery Risk Development in Young Adults (CARDIA) Study (black and white men and women, aver...
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